Summary

Name TNRC6B
Full Name Trinucleotide repeat-containing gene 6B protein
Synonyms TNR6B_HUMAN | KIAA1093
Primary ID Q9UPQ9
Links - -
Type protein
Relations 1
Function Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (PubMed:21981923).

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Relations

Regulator Mechanism target score ℹ
+ TNRC6Bup-regulates activity img/direct-activation.png binding AGO2 0.785
Publications: 1 Organism: In Vitro