+ |
AKT3 | up-regulates
phosphorylation
|
AGO2 |
0.439 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178416 |
Ser387 |
SKLMRSAsFNTDPYV |
Homo sapiens |
|
pmid |
sentence |
18476811 |
Phosphorylation of argonaute 2 at serine-387 facilitates its localization to processing bodies, akt3-mediated phosphorylation of ago2 is a molecular switch between target mrna cleavage and translational repression activities of ago2 |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-201918 |
Ser387 |
SKLMRSAsFNTDPYV |
Homo sapiens |
|
pmid |
sentence |
23603119 |
Phosphorylation of argonaute 2 at serine-387 facilitates its localization to processing bodies. , akt3-mediated phosphorylation of ago2 is a molecular switch between target mrna cleavage and translational repression activities of ago2 |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MAPKAPK2 | up-regulates
phosphorylation
|
AGO2 |
0.45 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-166615 |
Ser387 |
SKLMRSAsFNTDPYV |
Homo sapiens |
|
pmid |
sentence |
20626350 |
Mk2 was found to phopsphorylate in vitro the ago2 protein in ser387, which was identified as the major ago2 phosphorylation site in cells.and mutation of ser387 to alanineimpairsago2 localization to therna-containing granules termedprocessing bodies |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AGO2 | form complex
binding
|
DICER1/hAgo2/PRKRA |
0.806 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-143102 |
|
|
Homo sapiens |
|
pmid |
sentence |
23661684 |
|
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
AGO2 | form complex
binding
|
RISC(DICER1/AGO2/TARBP2) |
0.901 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-140220 |
|
|
Homo sapiens |
|
pmid |
sentence |
16142218 |
Dicer and trbp interact in vivo and in vitro /our data indicate that trbp is primarily required for the assembly and/or functioning of si_ or mi_riscs in mammalian cells, but it may also facilitate the cleavage of pre_mirnas by dicer. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TNRC6B | up-regulates activity
binding
|
AGO2 |
0.785 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-269680 |
|
|
in vitro |
|
pmid |
sentence |
17891150 |
The assay showed that full-length TNRC6B binds full-length human AGO2. We have identified and molecularly dissected important sequence and structure features in the conserved Ago hooks of S. pombe Tas3 and human TNRC6B. The effect of Ago hook peptides from the shuttling P-body component TNRC6B in our miRNA-mediated translational repression assay (Fig. 5b), in particular, hints at a novel regulatory role of Ago hooks in miRNA-mediated gene repression mechanisms. |
|
Publications: |
1 |
Organism: |
In Vitro |