3.0
Summary
| Name |  SMG5
|
| Full Name | Nonsense-mediated mRNA decay factor SMG5 |
| Synonyms | EST1-like protein B, LPTS-RP1, LPTS-interacting protein, SMG-5 homolog, hSMG-5 | EST1B, KIAA1089 |
| Primary ID | Q9UPR3 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}. |
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polyubiquitination
binding