Summary

Name GNE
Full Name Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Synonyms UDP-GlcNAc-2-epimerase/ManAc kinase | GLCNE
Primary ID Q9Y223
Links - -
Type protein
Relations 3
Function Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.

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Relations

Regulator Mechanism target score ℹ
+ GNEdown-regulates quantity img/direct_inhibition.png chemical modification UDP-N-acetyl-alpha-D-glucosamine 0.8
Publications: 1
+ PKCup-regulates activity img/direct-activation.png phosphorylation GNE 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Liver
+ GNEup-regulates quantity img/direct-activation.png chemical modification N-acyl-D-mannosamine 6-phosphate(2-) 0.8
Publications: 1