Summary

Name PDE10A
Full Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Synonyms PDE10_HUMAN
Primary ID Q9Y233
Links - -
Type protein
Relations 2
Inhibitors PF-2545920
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation PDE10A 0.375
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDE10A 0.8
Publications: 1 Organism: Homo Sapiens