Summary

Name NOD1
Full Name Nucleotide-binding oligomerization domain-containing protein 1
Synonyms Caspase recruitment domain-containing protein 4 | CARD4
Primary ID Q9Y239
Links - -
Type protein
Relations 3
Function Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding ATG16L1 0.667
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Autophagy 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NfKb-p65/p50 0.296
Publications: 1 Organism: Homo Sapiens