3.0
Summary
| Name |  RNF6
|
| Full Name | E3 ubiquitin-protein ligase RNF6 |
| Synonyms | RING-type E3 ubiquitin transferase RNF6 | SPG2 |
| Primary ID | Q9Y252 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. |
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polyubiquitination
ubiquitination