Summary
Name | LIMK1 View Modifications |
Full Name | LIM domain kinase 1 |
Synonyms | LIMK-1 | LIMK |
Primary ID | P53667 |
Links | - - |
Type | protein |
Relations | 9 |
Inhibitors | dabrafenib |
Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). |
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Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | LIMK1 | down-regulates phosphorylation | CFL1 | 0.809 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | LIMK1 | down-regulates activity phosphorylation | CFL2 | 0.689 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | MAPKAPK2 | up-regulates phosphorylation | LIMK1 | 0.367 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | ROCK1 | up-regulates activity phosphorylation | LIMK1 | 0.597 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | PAK1 | up-regulates activity phosphorylation | LIMK1 | 0.593 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | CDC42BPA | up-regulates activity phosphorylation | LIMK1 | 0.413 |
Publications: | 1 | |||
+ | PTPRG | down-regulates activity dephosphorylation | LIMK1 | 0.263 |
Publications: | 1 | Organism: | In Vitro | |
+ | RNF6 | down-regulates quantity by destabilization polyubiquitination | LIMK1 | 0.447 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | dabrafenib | down-regulates activity chemical inhibition | LIMK1 | 0.8 |
Publications: | 1 | Organism: | In Vitro | |