3.0
Summary
| Name |  CFL2View Modifications |
| Full Name | Cofilin-2 |
| Synonyms | Cofilin, muscle isoform |
| Primary ID | Q9Y281 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TESK1 | down-regulates activity 
phosphorylation
|
CFL2 | 0.329 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TESK2 | down-regulates activity
phosphorylation
|
CFL2 | 0.329 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LIMK1 | down-regulates activity
phosphorylation
|
CFL2 | 0.689 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CFL2 | down-regulates quantity
binding
|
F-actin_assembly | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |