+ |
TESK2 | down-regulates activity
phosphorylation
|
CFL2 |
0.327 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-246711 |
Ser3 |
sGVTVNDE |
Homo sapiens |
Testis |
pmid |
sentence |
11418599 |
Like TESK1, TESK2 phosphorylated cofilin specifically at Ser-3 and induced formation of actin stress fibers and focal adhesionsExpression of cofilin or S3A-cofilin into HeLa cells induced marked decreases in rhodamine-phalloidin staining due to the actin binding and -depolymerizing activity of cofilin |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TESK2 | down-regulates activity
phosphorylation
|
CFL1 |
0.518 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-108753 |
Ser3 |
sGVAVSDG |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11418599 |
Like tesk1, tesk2 phosphorylated cofilin specifically at ser-3 and induced formation of actin stress fibers and focal adhesions. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TESK2 | down-regulates activity
phosphorylation
|
DSTN |
0.432 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-246707 |
Ser3 |
sGVQVADE |
Homo sapiens |
Testis |
pmid |
sentence |
11418599 |
The present study provides evidence that TESK2 can phosphorylate cofilin and ADF specifically at Ser-3. Since actin-depolymerizing and -severing activities of cofilin/ADF are abrogated by phosphorylation at Ser-3, TESK2 seems to play an important role in actin filament dynamics by inhibiting cofilin/ADF activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |