Summary

Name MDC1
Full Name Mediator of DNA damage checkpoint protein 1
Synonyms Nuclear factor with BRCT domains 1 | KIAA0170, NFBD1
Primary ID Q14676
Links - -
Type protein
Relations 13
Function Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CSNK2A1up-regulates img/direct-activation.png phosphorylation MDC1 0.353
Publications: 6 Organism: Homo Sapiens
+ ASF1Aup-regulates activity img/direct-activation.png binding MDC1 0.317
Publications: 1 Organism: Homo Sapiens
+ L3MBTL2up-regulates activity img/direct-activation.png binding MDC1 0.2
Publications: 1 Organism: Homo Sapiens
+ BAZ1Bdown-regulates img/indirect_inhibition.png MDC1 0.371
Publications: 1 Organism: Homo Sapiens
+ H2AXup-regulates img/direct-activation.png binding MDC1 0.2
Publications: 1 Organism: Homo Sapiens
+ MDC1up-regulates img/direct-activation.png binding NBN 0.829
Publications: 1 Organism: Homo Sapiens
+ ATMup-regulates img/direct-activation.png phosphorylation MDC1 0.842
Publications: 1 Organism: Homo Sapiens
+ MDC1up-regulates img/direct-activation.png relocalization RNF8 0.749
Publications: 1 Organism: Homo Sapiens