Summary

Name NCKAP1
Full Name Nck-associated protein 1
Synonyms NAP 1, Membrane-associated protein HEM-2, p125Nap1 | HEM2, KIAA0587, NAP1
Primary ID Q9Y2A7
Links - -
Type protein
Relations 3
Function Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.

Viewer

Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding WAVE complex 0.925
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NHS 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding WRC complex 0.91
Publications: 1 Organism: Homo Sapiens