| + |
SIK3 | down-regulates activity 
phosphorylation
|
CRTC2 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249172 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249170 |
Ser348 |
PSLQSSLsNPNLQAS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249171 |
Ser70 |
RSSHYGGsLPNVNQI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
STK11 | up-regulates 
phosphorylation
|
SIK3 |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122835 |
Thr221 |
TPGQLLKtWCGSPPY |
Homo sapiens |
|
| pmid |
sentence |
| 14976552 |
Lkb1 is a master kinase that activates 13 kinases of the ampk subfamily, including mark/par-1we recently demonstrated that the lkb1 tumour suppressor kinase, in complex with the pseudokinase strad and the scaffolding protein mo25, phosphorylates and activates amp-activated protein kinase (ampk). A total of 12 human kinases (nuak1, nuak2, brsk1, brsk2, qik, qsk, sik, mark1, mark2, mark3, mark4 and melk) are related to ampk. Here we demonstrate that lkb1 can phosphorylate the t-loop of all the members of this subfamily, apart from melk, increasing their activity >50-fold |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SIK3
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