Summary

Name CRTC2
Full Name CREB-regulated transcription coactivator 2
Synonyms Transducer of regulated cAMP response element-binding protein 2, TORC-2, Transducer of CREB protein 2 | TORC2
Primary ID Q53ET0
Links - -
Type protein
Relations 25
Pathways FAP: GCR-cAMP crosstalk, Glycolysis and Gluconeogenesis
Function Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CRTC2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.419
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:Glycolysis and Gluconeogenesis
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.524
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.734
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CRTC2 0.618
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.467
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.629
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CRTC2 0.629
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NR3C1 0.301
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PCK1 0.401
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ up-regulates quantity img/direct-activation.png transcriptional regulation G6PC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation G6P 0.285
Publications: 2 Organism: Pongo Pygmaeus, Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ down-regulates img/indirect_inhibition.png CRTC2 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CREB1 0.908
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation TSC22D3 0.2
Publications: 1 Organism: Homo Sapiens