+ |
PLK1 | up-regulates activity
phosphorylation
|
SUGT1 |
0.448 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265222 |
Ser331 |
VKRAMNKsFMESGGT |
Homo sapiens |
|
pmid |
sentence |
22869522 |
Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment|Plk1 is required for the kinetochore localization of Sgt1 and phosphorylates serine 331 of Sgt1 at the kinetochores. This phosphorylation event enhances the association of the Hsp90-Sgt1 chaperone |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SUGT1 | up-regulates activity
relocalization
|
Ndc80 complex |
0.275 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265224 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
22869522 |
Here we identify Sgt1, a cochaperone for Hsp90, as a novel Plk1 substrate during mitosis|This phosphorylation event enhances the association of the Hsp90-Sgt1 chaperone with the MIS12 complex to stabilize this complex at the kinetochores and thus coordinates the recruitment of the NDC80 complex to form efficient microtubule-binding sites. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SUGT1 | up-regulates activity
binding
|
MIS12 complex |
0.307 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265223 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
22869522 |
Here we identify Sgt1, a cochaperone for Hsp90, as a novel Plk1 substrate during mitosis|This phosphorylation event enhances the association of the Hsp90-Sgt1 chaperone with the MIS12 complex to stabilize this complex at the kinetochores and thus coordinates the recruitment of the NDC80 complex to form efficient microtubule-binding sites. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |