| + |
ZDHHC9 | up-regulates activity 
palmitoylation
|
HRAS |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261352 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16000296 |
Covalent lipid modifications mediate the membrane attachment and biological activity of Ras proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine; H-Ras and N-Ras are further modified by palmitoylation. Here we report that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes. DHHC9 is an integral membrane protein that contains a DHHC cysteine-rich domain. GCP16 encodes a Golgi-localized membrane protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GOLGA7 | up-regulates activity
binding
|
ZDHHC9 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261353 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16000296 |
DHHC9 and GCP16 form a protein complex, and DHHC9 requires GCP16 for protein fatty acyltransferase activity and protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZDHHC9 | up-regulates activity
palmitoylation
|
NRAS |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261355 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16000296 |
Covalent lipid modifications mediate the membrane attachment and biological activity of Ras proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine; H-Ras and N-Ras are further modified by palmitoylation. Here we report that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes. DHHC9 is an integral membrane protein that contains a DHHC cysteine-rich domain. GCP16 encodes a Golgi-localized membrane protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZDHHC9
- 
- 