Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273807 |
Tyr195 |
PGGLDDRySLVSEQL |
Homo sapiens |
HaCaT Cell |
pmid |
sentence |
25501895 |
We have discovered that reactive oxygen species (ROS) trigger the c-Src kinase-mediated tyrosine (Tyr)-195 phosphorylation of PKP3. This modification is associated with a change in the subcellular distribution of the protein. Specifically, PKP3 bearing phospho-Tyr-195 is released from the desmosomes, suggesting that phospho-Tyr-195 is relevant for the control of desmosome disassembly and function, at least in cells exposed to ROS. |
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