| + |
GSK3A | down-regulates quantity by destabilization
phosphorylation
|
GPSM3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264863 |
Ser35 |
STTRPWRsAPPSPPP |
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 22843681 |
Co-immunoprecipitation of endogenous GPSM3 and 14-3-3 proteins from the human monocytic cell line THP-1 suggests basal phosphorylation of GPSM3 at serine 35 as potentially mediated by GSK3alpha. The GPSM3/14-3-3 interaction is seen to stabilize GPSM3 from degradation and also support the nuclear exclusion of both proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
14-3-3 | up-regulates quantity by stabilization
binding
|
GPSM3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264866 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 22843681 |
Mutation of serine 35 completely abrogates the 14-3-3 interaction (e.g. Fig. 2, B–F), suggesting that phosphorylation of serine 35 is obligatory for 14-3-3 binding|The GPSM3/14-3-3 interaction is seen to stabilize GPSM3 from degradation and also support the nuclear exclusion of both proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPSM3 | down-regulates activity
binding
|
GNAI1 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264864 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22843681 |
GPSM3 acts through its two GoLoco motifs to exert GDP dissociation inhibitor activity over Galpha(i) subunits|interactions between GPSM3 and Galphai1 or Gbeta1 (20) was assayed by BRET. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPSM3 | down-regulates quantity by destabilization
binding
|
GNB1 |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264865 |
|
|
|
|
| pmid |
sentence |
| 22843681 |
GPSM3 was found not only to modulate heterotrimeric G-protein subunit signaling through its two active GoLoco motifs, but also to affect monomeric Gbeta subunit biosynthesis and stability|interactions between GPSM3 and Galphai1 or Gbeta1 (20) was assayed by BRET. |
|
| Publications: |
1 |