3.0
Summary
| Name |  UBIAD1
|
| Full Name | UbiA prenyltransferase domain-containing protein 1 |
| Synonyms | Transitional epithelial response protein 1 | TERE1 |
| Primary ID | Q9Y5Z9 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme |
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