Name MRVI1
Full Name Protein MRVI1
Synonyms Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, JAW1-related protein MRVI1 | IRAG, JAW1L
Primary ID Q9Y6F6
Links - -
Type protein
Relations 1
Function Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.



Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MRVI1 0.08
Publications: 1 Organism: Homo Sapiens