3.0
Summary
| Name |  IRAG1
|
| Full Name | Inositol 1,4,5-triphosphate receptor associated 1 |
| Synonyms | Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate, JAW1-related protein MRVI1 | IRAG, JAW1L |
| Primary ID | Q9Y6F6 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. |
transcriptional regulation