| + |
CSNK1G3 | up-regulates quantity by stabilization 
phosphorylation
|
LYN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275395 |
Ser13 |
SKGKDSLsDDGVDLK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33004926 |
Although there have been more than 40 reports of mass spectrometric studies on phosphorylation at Lyn-S13, the kinase responsible remained unclear. We succeeded in identifying casein kinase 1γ (CK1γ) as the kinase responsible for phosphorylation of Lyn-S13. In HEK293 cells co-expressing Lyn and CK1γ, the phosphorylation level of Lyn-S13 increased significantly. we concluded that S-palmitoylated CK1γ encounters N-myristoylated Lyn and specifically phosphorylates the Ser-13 residue at the Golgi during intracellular protein traffic, as shown schematically in Fig. 8. Phosphorylated dual-lipid-modified Lyn and S-palmitoylated CK1γ are then transported from the Golgi to the plasma membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1G3 | up-regulates activity
phosphorylation
|
LRP6 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275400 |
Thr1479 |
SSSSTKGtYFPAILN |
Homo sapiens |
|
| pmid |
sentence |
| 35487243 |
Central to WNT signalosome formation is phosphorylation of LRP6 at multiple sites, with GSK3β phosphorylating LRP6 at S1490 and CK1 family members phosphorylating LRP6 at T1479 and T1493 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275401 |
Thr1493 |
NPPPSPAtERSHYTM |
Homo sapiens |
|
| pmid |
sentence |
| 35487243 |
Central to WNT signalosome formation is phosphorylation of LRP6 at multiple sites, with GSK3β phosphorylating LRP6 at S1490 and CK1 family members phosphorylating LRP6 at T1479 and T1493 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
CSNK1G3
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