| + |
DUSP10 | down-regulates activity 
dephosphorylation
|
IRF3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26305722 |
The inactivation of IRF3 by MKP5 is dependent on MKP5 phosphatase activity or its binding to IRF3.|This is confirmed since MKP5 phosphatasedeficient mutant is unable to dephosphorylate IRF3 and MKP5 mutant lacking IRF3 binding motifs fails to suppress IRF3 nuclear translocation upon virus infection. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP10 | down-regulates
dephosphorylation
|
MAPK8 |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68986 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10391943 |
Mkp-5 directly dephosphorylates sapk/jnk and p38 in vitromkp-5 binds to p38 and sapk/jnk, but not to mapk/erk, and inactivates p38 and sapk/jnk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP10 | down-regulates
dephosphorylation
|
MAPK14 |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68983 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10391943 |
Mkp-5 binds to p38 and sapk/jnk, but not to mapk/erk, and inactivates p38 and sapk/jnk, but not mapk/erk. p38 is a preferred substrate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
DUSP10
- 
- 