Summary

Name PIAS3
Full Name E3 SUMO-protein ligase PIAS3
Synonyms Protein inhibitor of activated STAT protein 3
Primary ID Q9Y6X2
Links - -
Type protein
Relations 5
Pathways IL6 Signaling, T-Lymphocyte: TGF beta
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).

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Relations

Regulator Mechanism target score ℹ
+ PIAS3form complex img/form-complex.png binding SMAD3/PIAS3 0.58
Publications: 1 Organism: Homo Sapiens
+ PIAS3down-regulates img/direct_inhibition.png sumoylation STAT3 0.72
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling
+ PIAS3up-regulates activity img/direct-activation.png binding SMAD3 0.58
Publications: 1 Organism: Homo Sapiens
+ PIAS3up-regulates img/direct-activation.png binding SMAD3 0.58
Publications: 1 Organism: Homo Sapiens
+ PIAS3down-regulates activity img/direct_inhibition.png binding STAT3 0.72
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling