| + |
SMAD3 | form complex 
binding
|
SMAD3/PIAS3 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255034 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26194464 |
In summary, the TGF-b/IL-6/TCR-pERK-Smad2L (Ser255) axis is the positive regulator, whereas unphosphorylated Smad3C-PIAS3 complex is the negative regulator of STAT3-induced transcriptional processes for TH17 differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIAS3 | form complex
binding
|
SMAD3/PIAS3 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26194464 |
In summary, the TGF-b/IL-6/TCR-ERK-Smad2L (Ser255) axis is the positive regulator, whereas unphosphorylated Smad3C-PIAS3 complex is the negative regulator of STAT3-induced transcriptional processes for TH17 differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3/PIAS3 | down-regulates 
|
STAT3 |
0.632 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255036 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26194464 |
In summary, the TGF-b/IL-6/TCR-pERK-Smad2L (Ser255) axis is the positive regulator, whereas unphosphorylated Smad3C-PIAS3 complex is the negative regulator of STAT3-induced transcriptional processes for TH17 differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SMAD3/PIAS3