| + |
MIOS | form complex 
binding
|
GATOR2 |
0.943 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255301 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23723239 |
Here, we identify GATOR as a complex that interacts with the Rags and is composed of two subcomplexes we call GATOR1 and 2. Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation. In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, Sec13) suppresses mTORC1 signaling and epistasis analysis shows that GATOR2 negatively regulates DEPDC5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SESN1 | down-regulates activity 
binding
|
GATOR2 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253559 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 25457612 |
We describe AMPK-independent mechanism of mTORC1 regulation by the Sestrins, in which the Sestrins inhibit mTORC1 localization to the lysosomes in a Rag-dependent manner through an interaction with GATOR2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WDR59 | form complex
binding
|
GATOR2 |
0.827 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23723239 |
Here, we identify GATOR as a complex that interacts with the Rags and is composed of two subcomplexes we call GATOR1 and 2. Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation. In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, Sec13) suppresses mTORC1 signaling and epistasis analysis shows that GATOR2 negatively regulates DEPDC5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SESN2 | down-regulates activity
binding
|
GATOR2 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253560 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 25457612 |
We describe AMPK-independent mechanism of mTORC1 regulation by the Sestrins, in which the Sestrins inhibit mTORC1 localization to the lysosomes in a Rag-dependent manner through an interaction with GATOR2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WDR24 | form complex
binding
|
GATOR2 |
0.905 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255302 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23723239 |
Here, we identify GATOR as a complex that interacts with the Rags and is composed of two subcomplexes we call GATOR1 and 2. Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation. In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, Sec13) suppresses mTORC1 signaling and epistasis analysis shows that GATOR2 negatively regulates DEPDC5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SESN3 | down-regulates activity
binding
|
GATOR2 |
0.452 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253561 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 25457612 |
We describe AMPK-independent mechanism of mTORC1 regulation by the Sestrins, in which the Sestrins inhibit mTORC1 localization to the lysosomes in a Rag-dependent manner through an interaction with GATOR2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SEC13 | form complex
binding
|
GATOR2 |
0.855 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255305 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23723239 |
Here, we identify GATOR as a complex that interacts with the Rags and is composed of two subcomplexes we call GATOR1 and 2. Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation. In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, Sec13) suppresses mTORC1 signaling and epistasis analysis shows that GATOR2 negatively regulates DEPDC5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GATOR2 | down-regulates activity
binding
|
GATOR1 |
0.825 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253564 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 23723238 |
Thus, GATOR2 is an inhibitor of an inhibitor (GATOR1) of the amino acid sensing branch of the TORC1 pathway |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SEH1L | form complex
binding
|
GATOR2 |
0.831 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255304 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23723239 |
Here, we identify GATOR as a complex that interacts with the Rags and is composed of two subcomplexes we call GATOR1 and 2. Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation. In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, Sec13) suppresses mTORC1 signaling and epistasis analysis shows that GATOR2 negatively regulates DEPDC5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GATOR2
CPX-6227