| + |
SMAD8/SMAD4 | up-regulates 
transcriptional regulation
|
RUNX2 |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255784 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27563484 |
Smad1/5/8-Smad4 complex transcribed Runx2 expression, as they complex with Runx2 to initiate other osteoblast gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR1A | up-regulates activity 
phosphorylation
|
SMAD8/SMAD4 |
0.69 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255786 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19620713 |
The expression of CA-BMPr1A and CA-BMPr1B mRNA was confirmed by RT-PCR using appropriate primers to distinguish expression of the constitutively active receptors from endogenous BMP receptors; specific antibodies for these receptors were not available. However, the functional effects of their expression, i.e., phosphorylation of Smad1/5/8 and p38 MAPK, verify overexpression of the constitutively active receptors (Fig. 3B). Thus, their overexpression provoked a substantial rise in the phosphorylation of Smad1/5/8 and p38 MAPK, known downstream phosphorylated intermediates in the BMP signaling pathway (Fig. 3B) (16, 17). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD4 | form complex 
binding
|
SMAD8/SMAD4 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255269 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD9 | form complex
binding
|
SMAD8/SMAD4 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255776 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9371779 |
As shown in Fig. 2, immunoprecipitation of Smad8 with an anti-myc antibody could bring down the Flag-tagged Smad4 only in the presence of CA-ALK-2, indicating that only activation of ALK-2 but not ALK-4 could induce the heteromerization of Smad8 with Smad4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255268 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus, Homo Sapiens |
3.0
SMAD8/SMAD4