| + |
CASP9 | form complex 
binding
|
Caspase 9 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256397 |
|
|
|
|
| pmid |
sentence |
| 29500231 |
The caspase-9 CARD has been thought to be principally involved in recruitment to the apoptosome, but its roles outside this interaction have yet to be uncovered. In this work, we show that the CARD is involved in physical interactions with the catalytic core of caspase-9 in the absence of the apoptosome; this interaction requires a properly formed caspase-9 active site. |
|
| Publications: |
1 |
| + |
Caspase 9 complex | up-regulates activity 
cleavage
|
CASP3 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256448 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15657060 |
Following autoprocessing in the apoptosome, caspase-9 cleaves and activates caspase-3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256462 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9390557 |
Activated caspase-9 in turn cleaves and activates caspase-3. Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
Caspase 9 complex
CPX-991