| + |
BLOC-2 | up-regulates activity 
binding
|
KIF13A |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260702 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30404817 |
Recycling endosomes (REs) are transient endosomal tubular intermediates of early/sorting endosomes (E/SEs) that function in cargo recycling to the cell surface and deliver the cell type-specific cargo to lysosome-related organelles such as melanosomes in melanocytes.|Taken together, these findings suggest that Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on E/SEs to generate REs that maintain cellular and organelle homeostasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HPS5 | form complex 
binding
|
BLOC-2 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260689 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15030569 |
Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS7 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB32 | up-regulates activity
relocalization
|
BLOC-2 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23247405 |
Rab32 and Rab38 interact physically and colocalize with BLOC-2, AP-1 and AP-3|These results indicate that Rab32 and Rab38 operate in the same pathways previously defined for AP-1, AP-3 and BLOC-2 and suggest they are the specific proteins that divert AP-1, AP-3 and BLOC-2-dependent cargoes to maturing melanosomes and away from lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB38 | up-regulates activity
relocalization
|
BLOC-2 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23247405 |
Rab32 and Rab38 interact physically and colocalize with BLOC-2, AP-1 and AP-3|These results indicate that Rab32 and Rab38 operate in the same pathways previously defined for AP-1, AP-3 and BLOC-2 and suggest they are the specific proteins that divert AP-1, AP-3 and BLOC-2-dependent cargoes to maturing melanosomes and away from lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB22A | up-regulates activity
relocalization
|
BLOC-2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260696 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30404817 |
Recycling endosomes (REs) are transient endosomal tubular intermediates of early/sorting endosomes (E/SEs) that function in cargo recycling to the cell surface and deliver the cell type-specific cargo to lysosome-related organelles such as melanosomes in melanocytes.|Taken together, these findings suggest that Rab22A promotes the assembly of a BLOC-1-BLOC-2-KIF13A complex on E/SEs to generate REs that maintain cellular and organelle homeostasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HPS3 | form complex
binding
|
BLOC-2 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260688 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15030569 |
Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HPS6 | form complex
binding
|
BLOC-2 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15030569 |
Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS8 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
BLOC-2
CPX-5044