| + |
BLOC-3 | up-regulates activity 
guanine nucleotide exchange factor
|
RAB32 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260693 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23174301 |
HPS1/HPS4 was active exclusively for RAB32 and RAB38. Moreover, when overexpressed with HPS1 in HeLa cells, a mitochondrially restricted form of HPS4 preferentially recruited GFP-tagged RAB32 or RAB38 – but not the related RAB7 or RAB9 – to mitochondria. Activity in both assays required both HPS1 and HPS4. Finally, depletion of HPS1 or HPS4 by siRNA in a pigmented human melanoma cell line, MNT-1, resulted in the mislocalization of RAB32. These data provide strong evidence that BLOC-3 is a selective GEF for RAB32 and RAB38 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB32 | up-regulates activity
relocalization
|
AP-3 complex |
0.291 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260698 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23247405 |
Rab32 and Rab38 interact physically and colocalize with BLOC-2, AP-1 and AP-3|These results indicate that Rab32 and Rab38 operate in the same pathways previously defined for AP-1, AP-3 and BLOC-2 and suggest they are the specific proteins that divert AP-1, AP-3 and BLOC-2-dependent cargoes to maturing melanosomes and away from lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB32 | up-regulates activity
relocalization
|
Neuronal AP-3 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268524 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23247405 |
Rab32 and Rab38 interact physically and colocalize with BLOC-2, AP-1 and AP-3|These results indicate that Rab32 and Rab38 operate in the same pathways previously defined for AP-1, AP-3 and BLOC-2 and suggest they are the specific proteins that divert AP-1, AP-3 and BLOC-2-dependent cargoes to maturing melanosomes and away from lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB32 | up-regulates activity
relocalization
|
BLOC-2 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260695 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23247405 |
Rab32 and Rab38 interact physically and colocalize with BLOC-2, AP-1 and AP-3|These results indicate that Rab32 and Rab38 operate in the same pathways previously defined for AP-1, AP-3 and BLOC-2 and suggest they are the specific proteins that divert AP-1, AP-3 and BLOC-2-dependent cargoes to maturing melanosomes and away from lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAB32 | up-regulates activity
relocalization
|
AP-1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260700 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23247405 |
Rab32 and Rab38 interact physically and colocalize with BLOC-2, AP-1 and AP-3|These results indicate that Rab32 and Rab38 operate in the same pathways previously defined for AP-1, AP-3 and BLOC-2 and suggest they are the specific proteins that divert AP-1, AP-3 and BLOC-2-dependent cargoes to maturing melanosomes and away from lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RAB32
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- 