| + |
SF3A3 | form complex 
binding
|
SF3a |
0.974 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263949 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 8349644 |
Components required for the splicing of nuclear messenger RNA precursors in vitro have been isolated from HeLa cells. Here we describe the separation of splicing factor SF3 into two components, SF3a and SF3b. SF3a has been purified to homogeneity by a combination of ion-exchange chromatography, gel filtration, and glycerol gradient sedimentation. It consists of a complex of three polypeptides of 60, 66, and 120 kDa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHD1 | up-regulates activity 
binding
|
SF3a |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263951 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18042460 |
CHD1 was found to bridge core spliceosomal components to H3K4me3 via specific interactions with the SF3a sub-complex of U2 snRNP. The recruitment of SF3a and the efficiency of pre-mRNA splicing were perturbed upon reduction of CHD1 and H3K4me3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SF3A2 | form complex
binding
|
SF3a |
0.959 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263947 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 8349644 |
Components required for the splicing of nuclear messenger RNA precursors in vitro have been isolated from HeLa cells. Here we describe the separation of splicing factor SF3 into two components, SF3a and SF3b. SF3a has been purified to homogeneity by a combination of ion-exchange chromatography, gel filtration, and glycerol gradient sedimentation. It consists of a complex of three polypeptides of 60, 66, and 120 kDa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SF3A1 | form complex
binding
|
SF3a |
0.973 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263948 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 8349644 |
Components required for the splicing of nuclear messenger RNA precursors in vitro have been isolated from HeLa cells. Here we describe the separation of splicing factor SF3 into two components, SF3a and SF3b. SF3a has been purified to homogeneity by a combination of ion-exchange chromatography, gel filtration, and glycerol gradient sedimentation. It consists of a complex of three polypeptides of 60, 66, and 120 kDa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SF3a | up-regulates 
|
Spliceosomal_snRNP_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8349644 |
Components required for the splicing of nuclear messenger RNA precursors in vitro have been isolated from HeLa cells. Here we describe the separation of splicing factor SF3 into two components, SF3a and SF3b. SF3a has been purified to homogeneity by a combination of ion-exchange chromatography, gel filtration, and glycerol gradient sedimentation. It consists of a complex of three polypeptides of 60, 66, and 120 kDa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SF3a
CPX-2565