| + |
SF3a | up-regulates 
|
Spliceosomal_snRNP_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263950 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8349644 |
Components required for the splicing of nuclear messenger RNA precursors in vitro have been isolated from HeLa cells. Here we describe the separation of splicing factor SF3 into two components, SF3a and SF3b. SF3a has been purified to homogeneity by a combination of ion-exchange chromatography, gel filtration, and glycerol gradient sedimentation. It consists of a complex of three polypeptides of 60, 66, and 120 kDa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SF3b | up-regulates
|
Spliceosomal_snRNP_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268414 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32140746 |
The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMN complex | up-regulates
|
Spliceosomal_snRNP_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9323129 |
These findings suggest a role for SMN and SIP1 in spliceosomal snRNP biogenesis and function and provide a likely molecular mechanism for the cause of SMA |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
U2AF1/U2AF2 | up-regulates
|
Spliceosomal_snRNP_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11739736 |
The essential splicing factor U2AF (U2 auxiliary factor) is a heterodimer composed of 65-kDa (U2AF(65)) and 35-kDa (U2AF(35)) subunits. U2AF(35) has multiple functions in pre-mRNA splicing. First, U2AF(35) has been shown to function by directly interacting with the AG at the 3' splice site. Second, U2AF(35) is thought to play a role in the recruitment of U2AF(65) by serine-arginine-rich (SR) proteins in enhancer-dependent splicing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZRSR2/U2AF2 | up-regulates
|
Spliceosomal_snRNP_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263946 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11739736 |
The essential splicing factor U2AF (U2 auxiliary factor) is a heterodimer composed of 65-kDa (U2AF(65)) and 35-kDa (U2AF(35)) subunits. U2AF(35) has multiple functions in pre-mRNA splicing. First, U2AF(35) has been shown to function by directly interacting with the AG at the 3' splice site. Second, U2AF(35) is thought to play a role in the recruitment of U2AF(65) by serine-arginine-rich (SR) proteins in enhancer-dependent splicing. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CWC27 | up-regulates
|
Spliceosomal_snRNP_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261148 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11991638 |
Purification and characterization of native pliceosomes suitable for three-dimensional structural analysis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Spliceosomal_snRNP_assembly