3.0
Summary
| Name |  DGCR8View Modifications |
| Full Name | Microprocessor complex subunit DGCR8 |
| Synonyms | DiGeorge syndrome critical region 8 | C22orf12, DGCRK6 |
| Primary ID | Q8WYQ5 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates quantity by stabilization 
phosphorylation
|
DGCR8 | 0.273 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ABL1 | up-regulates activity
phosphorylation
|
DGCR8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DGCR8 | form complex 
binding
|
Microprocessor complex | 0.922 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DGCR8 | up-regulates activity
binding
|
RNF168 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | USP1 | up-regulates quantity by stabilization
deubiquitination
|
DGCR8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |