Relation Results

Summary

Name SMC5/6
Primary ID SIGNOR-C374
Links CPX-6086
Type complex
Formed by SMC5, SMC6, NSMCE1, NSMCE2, NSMCE3, NSMCE4A
Relations 8

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Type: Score: Layout: SPV 
0.20.8260.70.8790.8920.8970.70.874NSMCE3SMC5/6 NSMCE4ADNA_repairNSMCE2SMC5SMC6Chromosome_segregationNSMCE1

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Relations
Regulator
Mechanism
target
score ℹ
+ NSMCE3form complex img/form-complex.png binding SMC5/6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265485 in vitro
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: In Vitro
+ NSMCE4Aform complex img/form-complex.png binding SMC5/6 0.826
Identifier Residue Sequence Organism Cell Line
SIGNOR-265486 in vitro
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: In Vitro
+ SMC5/6 up-regulates img/indirect-activation.png DNA_repair 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265487 Homo sapiens
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: Homo Sapiens
+ NSMCE2form complex img/form-complex.png binding SMC5/6 0.879
Identifier Residue Sequence Organism Cell Line
SIGNOR-265484 in vitro
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: In Vitro
+ SMC5form complex img/form-complex.png binding SMC5/6 0.892
Identifier Residue Sequence Organism Cell Line
SIGNOR-265481 in vitro
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: In Vitro
+ SMC6form complex img/form-complex.png binding SMC5/6 0.897
Identifier Residue Sequence Organism Cell Line
SIGNOR-265482 in vitro
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: In Vitro
+ SMC5/6 up-regulates img/indirect-activation.png Chromosome_segregation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265488 Homo sapiens
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: Homo Sapiens
+ NSMCE1form complex img/form-complex.png binding SMC5/6 0.874
Identifier Residue Sequence Organism Cell Line
SIGNOR-265483 in vitro
pmid sentence
The SMC5/6 complex, consisting of SMC5, SMC6, and non-SMC elements NSMCE1–6, has key roles in the maintenance of chromosome integrity during mitotic proliferation, meiosis, and DNA repair and is critical for genome stability. In particular, the SMC5/6 complex is involved in resolving intermediates during recombination (5, 6) and other complex DNA structures, such as stalled replication forks
Publications: 1 Organism: In Vitro
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