| + |
ESCRT-III | up-regulates 
|
Membrane_fusion |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280937 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
In vivo and in vitro data suggest a key role for the ESCRT-III complex in all ESCRT-mediated membrane remodeling (budding and scission) reactions, although the mechanism is not understood. Hence, ESCRT-III filaments may have a dual role during MVB sorting: cargo sequestration within the site of MVB vesicle formation and membrane budding/scission. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265536 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CHMP1A | form complex 
binding
|
ESCRT-III |
0.639 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265531 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP2B | form complex
binding
|
ESCRT-III |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265530 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP6 | form complex
binding
|
ESCRT-III |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265526 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP4B | form complex
binding
|
ESCRT-III |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265533 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP4A | form complex
binding
|
ESCRT-III |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265529 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP3 | form complex
binding
|
ESCRT-III |
0.748 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265523 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ESCRT-III | up-regulates
|
Viral_budding |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265534 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHMP2A | form complex
binding
|
ESCRT-III |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265532 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP5 | form complex
binding
|
ESCRT-III |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265527 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP7 | form complex
binding
|
ESCRT-III |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265525 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP4C | form complex
binding
|
ESCRT-III |
0.654 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265528 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CHMP1B | form complex
binding
|
ESCRT-III |
0.721 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265524 |
|
|
in vitro |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. ESCRT-III subunits (CHMPs, for Charged Multivesicular Body Proteins [32], or Chromatin Modifying Proteins [33]) transition between soluble and polymerising states, and assemble in a defined order to form a membrane-remodeling filament that brings about membrane fission. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
ESCRT-III | up-regulates
|
Multivesicular_body_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
In vivo and in vitro data suggest a key role for the ESCRT-III complex in all ESCRT-mediated membrane remodeling (budding and scission) reactions, although the mechanism is not understood. Hence, ESCRT-III filaments may have a dual role during MVB sorting: cargo sequestration within the site of MVB vesicle formation and membrane budding/scission. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESCRT-II complex | up-regulates quantity 
binding
|
ESCRT-III |
0.668 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280933 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22361144 |
While cargo is collected, ESCRT-I together with ESCRT-II could initiate the budding process of the endosomal membrane. At the same time, both arms of ESCRT-II (Vps25/Eap20) could already interact with one copy of the first ESCRT-III subunit, Vps20/CHMP6 (charged multi-vesicular body protein 6), and convert it into an active nucleator for ESCRT-III assembly on endosomes.In contrast to the early ESCRT complexes (ESCRT-0, -I and -II), which form stable protein complexes in the cytoplasm, the ESCRT-III complex only transiently assembles on endosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESCRT-III | up-regulates
|
Cytoskeleton_organization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265535 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26775243 |
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
ESCRT-III
CPX-329