| + |
IPP complex | up-regulates activity 
relocalization
|
ACTB |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265768 |
|
|
|
|
| pmid |
sentence |
| 27590440 |
Apart from binding with integrins on the membrane, IPP complex can interact with the cytoskeleton as well as many signaling proteins inside the cell. Up to now, dozens of IPP complex-related proteins have been identified. One of these proteins is parvin that binds to F-actin, thus connecting ECM with cytoskeleton.17 In the following, we will discuss PINCH-interacting proteins and their roles. |
|
| Publications: |
1 |
| + |
LIMS2 | form complex 
binding
|
IPP complex |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265764 |
|
|
|
|
| pmid |
sentence |
| 16493410 |
Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and connects the ECM with the actin cytoskeleton. |
|
| Publications: |
1 |
| + |
LIMS4 | form complex
binding
|
IPP complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265766 |
|
|
|
|
| pmid |
sentence |
| 16493410 |
Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and connects the ECM with the actin cytoskeleton. |
|
| Publications: |
1 |
| + |
ILK | form complex
binding
|
IPP complex |
0.894 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265762 |
|
|
|
|
| pmid |
sentence |
| 16493410 |
Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and connects the ECM with the actin cytoskeleton. |
|
| Publications: |
1 |
| + |
LIMS3 | form complex
binding
|
IPP complex |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265765 |
|
|
|
|
| pmid |
sentence |
| 16493410 |
Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and connects the ECM with the actin cytoskeleton. |
|
| Publications: |
1 |
| + |
PXN | up-regulates activity
relocalization
|
IPP complex |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265767 |
|
|
|
|
| pmid |
sentence |
| 16493410 |
Integrin-linked kinase (ILK), and isoforms of particularly interesting Cys-His-rich protein (PINCH) and parvin form the IPP complex (Fig. 2) in the cytoplasm, and this complex is recruited to focal adhesions through interactions with other factors, such as paxillin. |
|
| Publications: |
1 |
| + |
PARVA | form complex
binding
|
IPP complex |
0.729 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265761 |
|
|
|
|
| pmid |
sentence |
| 16493410 |
Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and connects the ECM with the actin cytoskeleton. |
|
| Publications: |
1 |
| + |
LIMS1 | form complex
binding
|
IPP complex |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265763 |
|
|
|
|
| pmid |
sentence |
| 16493410 |
Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and connects the ECM with the actin cytoskeleton. |
|
| Publications: |
1 |
3.0
IPP complex