+ |
MAPK1 | up-regulates activity
phosphorylation
|
PARVA |
0.262 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265760 |
Ser4 |
sPQKSPSV |
Homo sapiens |
|
pmid |
sentence |
22955285 |
Actopaxin (alpha-parvin) is a paxillin, integrin-linked kinase, and F-actin binding focal adhesion protein with several serine phosphorylation sites in the amino terminus that contribute to the regulation of cell spreading and migration.|Actopaxin phosphorylation of Ser4/8 enhances cell migration whereas a nonphosphorylatable (Quint) mutant suppresses migration in U2OS osteosarcoma cells (7). |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265759 |
Ser8 |
MATSPQKsPSVPKSP |
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
22955285 |
Actopaxin (alpha-parvin) is a paxillin, integrin-linked kinase, and F-actin binding focal adhesion protein with several serine phosphorylation sites in the amino terminus that contribute to the regulation of cell spreading and migration.|Actopaxin phosphorylation of Ser4/8 enhances cell migration whereas a nonphosphorylatable (Quint) mutant suppresses migration in U2OS osteosarcoma cells (7). |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
PARVA | form complex
binding
|
IPP complex |
0.729 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265761 |
|
|
|
|
pmid |
sentence |
16493410 |
Integrin-linked kinase (ILK), PINCH and parvin form a ternary complex (the IPP complex) that binds to ECM-ligated integrins. This complex regulates signalling pathways and connects the ECM with the actin cytoskeleton. |
|
Publications: |
1 |