| + |
RUVBL2 | form complex 
binding
|
R2TP core co-chaperone |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29662061 |
Here we use cryo-EM and biochemical studies on the human R2TP core (RUVBL1-RUVBL2-RPAP3-PIH1D1) which reveal the distinctive role of RPAP3, distinguishing metazoan R2TP from the smaller yeast equivalent. RPAP3 spans both faces of a single RUVBL ring, providing an extended scaffold that recruits clients and provides a flexible tether for HSP90. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPAP3 | form complex
binding
|
R2TP core co-chaperone |
0.894 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270927 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29662061 |
Here we use cryo-EM and biochemical studies on the human R2TP core (RUVBL1-RUVBL2-RPAP3-PIH1D1) which reveal the distinctive role of RPAP3, distinguishing metazoan R2TP from the smaller yeast equivalent. RPAP3 spans both faces of a single RUVBL ring, providing an extended scaffold that recruits clients and provides a flexible tether for HSP90. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
R2TP core co-chaperone | form complex
binding
|
PAQosome co-chaperone complex |
0.658 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270925 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30484152 |
The PAQosome (Particle for Arrangement of Quaternary structure) is a large multisubunit chaperone complex that is essential for the assembly and stabilization of other macromolecular complexes. It also interacts with several chaperones including Hsp90, Hsp70, and CCT. The PAQosome is comprised of the R2TP complex, the URI1 prefoldin complex (also known as the non-canonical prefoldin-like complex), the RNA polymerase subunit RPB5, and the WD40 repeat protein WDR92. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUVBL1 | form complex
binding
|
R2TP core co-chaperone |
0.811 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29662061 |
Here we use cryo-EM and biochemical studies on the human R2TP core (RUVBL1-RUVBL2-RPAP3-PIH1D1) which reveal the distinctive role of RPAP3, distinguishing metazoan R2TP from the smaller yeast equivalent. RPAP3 spans both faces of a single RUVBL ring, providing an extended scaffold that recruits clients and provides a flexible tether for HSP90. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIH1D1 | form complex
binding
|
R2TP core co-chaperone |
0.843 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270926 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29662061 |
Here we use cryo-EM and biochemical studies on the human R2TP core (RUVBL1-RUVBL2-RPAP3-PIH1D1) which reveal the distinctive role of RPAP3, distinguishing metazoan R2TP from the smaller yeast equivalent. RPAP3 spans both faces of a single RUVBL ring, providing an extended scaffold that recruits clients and provides a flexible tether for HSP90. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
R2TP core co-chaperone
CPX-6143