| + |
iron(2+) | down-regulates quantity 
binding
|
Ferritin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279882 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
Fe3+ is taken up by TFRC and exported by SLC40A1. Inside the cell, Fe3+ is reduced to Fe2+, with excess iron stored in ferritin (composed of FTH1 and FTL) or sequestered by MT1G. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FTL | form complex 
|
Ferritin |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279858 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
Ferritin is a spherical protein complex composed of 24 subunits, which include two types: the heavy chain (FTH1) and the light chain (FTL). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FTH1 | form complex
|
Ferritin |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
Ferritin is a spherical protein complex composed of 24 subunits, which include two types: the heavy chain (FTH1) and the light chain (FTL). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2L2 | up-regulates quantity by expression 
transcriptional regulation
|
Ferritin |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification. In HCC cells, NFE2L2-mediated upregulation of FTH1 enhances the cellular antioxidant defense by increasing the capacity for iron storage, thereby reducing erastin- or sorafenib-induced ferroptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Ferritin