| + |
GET1 | form complex 
binding
|
GET complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32910895 |
Here, we present cryo-electron microscopy reconstructions, native mass spectrometry, and structure-based mutagenesis of human WRB/CAML/TRC40 and yeast Get1/Get2/Get3 complexes. Get3 binding to the membrane insertase supports heterotetramer formation, and phosphatidylinositol binding at the heterotetramer interface stabilizes the insertase for efficient TA insertion in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GET3 | form complex
binding
|
GET complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32910895 |
Here, we present cryo-electron microscopy reconstructions, native mass spectrometry, and structure-based mutagenesis of human WRB/CAML/TRC40 and yeast Get1/Get2/Get3 complexes. Get3 binding to the membrane insertase supports heterotetramer formation, and phosphatidylinositol binding at the heterotetramer interface stabilizes the insertase for efficient TA insertion in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMLG | form complex
binding
|
GET complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32910895 |
Here, we present cryo-electron microscopy reconstructions, native mass spectrometry, and structure-based mutagenesis of human WRB/CAML/TRC40 and yeast Get1/Get2/Get3 complexes. Get3 binding to the membrane insertase supports heterotetramer formation, and phosphatidylinositol binding at the heterotetramer interface stabilizes the insertase for efficient TA insertion in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GET complex | up-regulates 
|
Protein_insertion_into_membrane |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25043001 |
The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. The Get3 endoplasmic-reticulum receptor comprises the cytosolic domains of the Get1/2 (WRB/CAML) transmembrane complex, which interact individually with the targeting factor to drive a conformational change that enables substrate release and, as a consequence, insertion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GET complex