| + |
Endoplasmic reticulum membrane complex, EMC8 variant | up-regulates 
|
Protein_insertion_into_membrane |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280656 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32439656 |
A defining step in the biogenesis of a membrane protein is the insertion of its hydrophobic transmembrane helices into the lipid bilayer. The nine-subunit endoplasmic reticulum (ER) membrane protein complex (EMC) is a conserved co- and posttranslational insertase at the ER. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GET complex | up-regulates
|
Protein_insertion_into_membrane |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25043001 |
The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. The Get3 endoplasmic-reticulum receptor comprises the cytosolic domains of the Get1/2 (WRB/CAML) transmembrane complex, which interact individually with the targeting factor to drive a conformational change that enables substrate release and, as a consequence, insertion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAT intramembrane chaperone complex | up-regulates
|
Protein_insertion_into_membrane |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281082 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32814900 |
Here we identify the PAT complex, an abundant obligate heterodimer of the widely conserved ER-resident membrane proteins CCDC47 and Asterix. The PAT complex engages nascent TMDs that contain unshielded hydrophilic side chains within the lipid bilayer, and it disengages concomitant with substrate folding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Endoplasmic reticulum membrane complex- EMC9 variant | up-regulates
|
Protein_insertion_into_membrane |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280646 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32439656 |
The nine-subunit ER membrane protein complex (EMC) is a conserved co- and post-translational insertase at the endoplasmic reticulum. We determined the structure of the human EMC in a lipid nanodisc to an overall resolution of 3.4 Å by cryo-electron microscopy, permitting building of a nearly complete atomic model. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Protein_insertion_into_membrane