| + |
PPHLN1 | form complex 
binding
|
HUSH epigenetic repressor complex |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281013 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33144593 |
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of interferon-stimulated genes (ISGs) through JAK/STAT signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MPHOSPH8 | form complex
binding
|
HUSH epigenetic repressor complex |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281014 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33144593 |
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of interferon-stimulated genes (ISGs) through JAK/STAT signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TASOR | form complex
binding
|
HUSH epigenetic repressor complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281015 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33144593 |
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of interferon-stimulated genes (ISGs) through JAK/STAT signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HUSH epigenetic repressor complex | up-regulates activity 
binding
|
MORC2 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281016 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33144593 |
The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary fibroblasts leads to induction of interferon-stimulated genes (ISGs) through JAK/STAT signaling. It is associated with H3K9me3-dense genomic regions, including the 3 prime ends of zinc finger genes and functions to repress zinc finger genes and ribosomal DNAs25–27. The HUSH complex partners with the chromatin regulator MORC2, which contains a zinc finger and an ATPase domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
HUSH epigenetic repressor complex