Relation Results

Summary

Name MORC2
Full Name ATPase MORC2
Synonyms EC 3.6.1.-, MORC family CW-type zinc finger protein 2, Zinc finger CW-type coiled-coil domain protein 1 | KIAA0852, ZCWCC1
Primary ID Q9Y6X9
Links - -
Type protein
Relations 6
Function Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity ...
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Type: Score: Layout: SPV 
0.3680.20.20.2PAK1MORC2PRKACACDK1NAT10

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PAK1up-regulates activity img/direct-activation.png phosphorylation MORC2 0.368
Identifier Residue Sequence Organism Cell Line
SIGNOR-278414 Ser739 ATPSRKRsVAVSDEE Homo sapiens
pmid sentence
In support of this notion, selective knockdown of endogenous PAK1 significantly reduced the association of MORC2 with chromatin (XREF_FIG, compare lane 4 with 3).|PAK1 phosphorylation of MORC2 on serine 739 regulates an ATPase-dependent chromatin remodeling following DSB damage and facilitates efficient DSB repair.
Identifier Residue Sequence Organism Cell Line
SIGNOR-273714 Ser739 ATPSRKRsVAVSDEE Homo sapiens BGC-823 Cell
pmid sentence
We demonstrate that PAK1-mediated MORC2 phosphorylation promotes cell cycle progression, defective phosphorylation of MORC2-S677A results in attenuated cell proliferation and tumorigenicity of gastric cancer cells, which is significantly enhanced in overexpression of phospho-mimic MORC2-S677E form, suggesting the importance of MORC2 phosphorylation in tumorigenesis. 
Publications: 2 Organism: Homo Sapiens
+ PRKACAup-regulates quantity by stabilization img/direct-activation.png phosphorylation MORC2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273781 Thr582 LEALQKTtPIRSQAD Homo sapiens HEK-293 Cell
pmid sentence
Mechanistically, GPER1 activates PRKACA (protein kinase cAMP-activated catalytic subunit alpha), which in turn phosphorylates MORC2 at threonine 582 (T582). Phosphorylated MORC2 decreases its interaction with HSPA8 (heat shock protein family A [Hsp70] member 8) and LAMP2A (lysosomal associated membrane protein 2A), two core components of the chaperone-mediated autophagy (CMA) machinery, thus protecting MORC2 from lysosomal degradation by CMA.
Publications: 1 Organism: Homo Sapiens
+ CDK1down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MORC2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277837 Thr717 PSPKVIKtPVVKKTE Homo sapiens HeLa Cell
pmid sentence
Mechanically, PTX and VCR activate cyclin-dependent kinase 1, which in turn induces MORC2 phosphorylation at threonine 717 (T717) and T733. Phosphorylated MORC2 enhances its interation with HSPA8 and LAMP2A, two essential components of the chaperone-mediated autophagy (CMA) mechinery, resulting in its autophagic degradation.
Identifier Residue Sequence Organism Cell Line
SIGNOR-277838 Thr733 PIKLSPAtPSRKRSV Homo sapiens HeLa Cell
pmid sentence
Mechanically, PTX and VCR activate cyclin-dependent kinase 1, which in turn induces MORC2 phosphorylation at threonine 717 (T717) and T733. Phosphorylated MORC2 enhances its interation with HSPA8 and LAMP2A, two essential components of the chaperone-mediated autophagy (CMA) mechinery, resulting in its autophagic degradation.
Publications: 2 Organism: Homo Sapiens
+ MORC2up-regulates activity img/direct-activation.png binding NAT10 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273716 Homo sapiens HEK-293 Cell
pmid sentence
MORC2 directly interacts with PARP1. MORC2 mediates the interaction between PARP1 and NAT10 and thereby promotes NAT10-mediated PARP1 acetylation at K949, which blocks CHFR-mediated ubiquitination and degradation of PARP1.
Publications: 1 Organism: Homo Sapiens
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