| + |
CCZ1B | form complex 
binding
|
MON1-CCZ1B guanyl-nucleotide exchange factor complex, MON1A variant |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281044 |
|
|
|
|
| pmid |
sentence |
| 33144569 |
We conclude that mammalian Mon1, Ccz1 and C18orf8 form a stable trimeric complex, the MCC complex, of which C18orf8 is a core component. The Mon1-Ccz1-C18orf8 complex is responsible for mammalian Rab7 activation. The trimeric Mon1-Ccz1-C18orf8 (MCC) complex therefore acts as an activating GEF for mammalian Rab7 and its role in late endosomal trafficking and LDL-cholesterol uptake can be specifically by-passed by a constitutively active Rab7 (Q67L) or by Rab7GAP depletion. |
|
| Publications: |
1 |
| + |
MON1A | form complex
binding
|
MON1-CCZ1B guanyl-nucleotide exchange factor complex, MON1A variant |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281045 |
|
|
|
|
| pmid |
sentence |
| 33144569 |
We conclude that mammalian Mon1, Ccz1 and C18orf8 form a stable trimeric complex, the MCC complex, of which C18orf8 is a core component. The Mon1-Ccz1-C18orf8 complex is responsible for mammalian Rab7 activation. The trimeric Mon1-Ccz1-C18orf8 (MCC) complex therefore acts as an activating GEF for mammalian Rab7 and its role in late endosomal trafficking and LDL-cholesterol uptake can be specifically by-passed by a constitutively active Rab7 (Q67L) or by Rab7GAP depletion. |
|
| Publications: |
1 |
| + |
RMC1 | form complex
binding
|
MON1-CCZ1B guanyl-nucleotide exchange factor complex, MON1A variant |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281046 |
|
|
|
|
| pmid |
sentence |
| 33144569 |
We conclude that mammalian Mon1, Ccz1 and C18orf8 form a stable trimeric complex, the MCC complex, of which C18orf8 is a core component. The Mon1-Ccz1-C18orf8 complex is responsible for mammalian Rab7 activation. The trimeric Mon1-Ccz1-C18orf8 (MCC) complex therefore acts as an activating GEF for mammalian Rab7 and its role in late endosomal trafficking and LDL-cholesterol uptake can be specifically by-passed by a constitutively active Rab7 (Q67L) or by Rab7GAP depletion. |
|
| Publications: |
1 |
| + |
MON1-CCZ1B guanyl-nucleotide exchange factor complex, MON1A variant | up-regulates activity 
guanine nucleotide exchange factor
|
RAB7A |
0.717 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281047 |
|
|
|
|
| pmid |
sentence |
| 33144569 |
We conclude that mammalian Mon1, Ccz1 and C18orf8 form a stable trimeric complex, the MCC complex, of which C18orf8 is a core component. The Mon1-Ccz1-C18orf8 complex is responsible for mammalian Rab7 activation. The trimeric Mon1-Ccz1-C18orf8 (MCC) complex therefore acts as an activating GEF for mammalian Rab7 and its role in late endosomal trafficking and LDL-cholesterol uptake can be specifically by-passed by a constitutively active Rab7 (Q67L) or by Rab7GAP depletion. |
|
| Publications: |
1 |
4.0
MON1-CCZ1B guanyl-nucleotide exchange factor complex, MON1A variant