| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 41042035 |
Assembly of Lp(a) occurs in a two-step process: first, there is a non-covalent interaction between the KIV-5 and KIV-8 domains of apo(a) and the N terminus of apoB. Then a covalent disulfide bond forms between the unpaired KIV-9 cysteine on apo(a) and the unpaired cysteine 4326 in apoB, yielding a mature Lp(a) particle. Notably, recent research has led to the development of small molecule inhibitors such as muvalaplin that can prevent the initial apo(a)-apoB interaction, thus blocking Lp(a) particle assembly. |
|
4.0
Lp(a)
binding