| + |
LPA | down-regulates quantity by destabilization 
cleavage
|
FN1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282720 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2531657 |
The plasma concentration of human lipoprotein(a) [Lp(a)] is correlated with the risk of heart disease.The binding of Lp(a) was localized to the C-terminal heparin-binding domain of fibronectin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL6 | up-regulates quantity by expression 
transcriptional regulation
|
LPA |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282721 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 41042035 |
For example, interleukin 6 (IL-6) can induce apo(a) synthesis by triggering the promoter region on the LPA gene, and IL-6 blockade with tocilizumab significantly reduced Lp(a) levels via transcriptional suppression of the LPA gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | down-regulates quantity by repression 
transcriptional regulation
|
LPA |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282722 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 41042035 |
Recent evidence suggests that this IL-6-mediated induction is negatively regulated by peroxisome proliferator-activated receptor gamma (PPARg), as genetic and in vitro studies have shown that PPARg suppresses IL-6-driven LPA transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LPA | form complex 
binding
|
Lp(a) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 41042035 |
Assembly of Lp(a) occurs in a two-step process: first, there is a non-covalent interaction between the KIV-5 and KIV-8 domains of apo(a) and the N terminus of apoB. Then a covalent disulfide bond forms between the unpaired KIV-9 cysteine on apo(a) and the unpaired cysteine 4326 in apoB, yielding a mature Lp(a) particle. Notably, recent research has led to the development of small molecule inhibitors such as muvalaplin that can prevent the initial apo(a)-apoB interaction, thus blocking Lp(a) particle assembly. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
LPA
- 
- 