| + |
Netrin | up-regulates activity 
binding
|
UNC5 |
0.85 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25881791 |
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Axon guidance |
| + |
Netrin | up-regulates activity
binding
|
NEO1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268172 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21558366 |
In mammals, three secreted netrins, netrin 1, 3 and 4, and two membrane-tethered glycophosphatidylinositol (GPI)-linked (see Glossary, Box 1) netrins, netrin G1 and G2, have been identified. In mammals, receptors for the secreted netrins include deleted in colorectal cancer (DCC), the DCC paralogue neogenin, the UNC-5 homologues UNC5A-D, and Down syndrome cell adhesion molecule (DSCAM). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Nervous System |
| Pathways: | Axon guidance |
| + |
Netrin | up-regulates activity
binding
|
DSCAM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268173 |
|
|
Mus musculus |
Spinal Cord |
| pmid |
sentence |
| 18585357 |
Here, we report that the Down's syndrome Cell Adhesion Molecule (DSCAM), a candidate gene implicated in the mental retardation phenotype of Down's syndrome, is expressed on spinal commissural axons, binds netrin-1, and is necessary for commissural axons to grow toward and across the midline. DSCAM and DCC can each mediate a turning response of these neurons to netrin-1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Axon guidance |
3.0
Netrin