| + |
NLRC4 inflammasome | up-regulates 
|
Pyroptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30166988 |
Once activated by a ligand, inflammasomes lead to the activation of a caspase. Activated caspases allow the release of mature forms of interleukin-1β and interleukin-18 and trigger a specific pro-inflammatory cell death termed pyroptosis. Accumulating data suggest that inflammasomes, mainly NLRP3, NLRP1, and AIM2, are involved in the generation of tissue damage and immune dysfunction after trauma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inflammosome Activation |
| + |
NLRP1 inflammasome | up-regulates
|
Pyroptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260355 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30166988 |
Once activated by a ligand, inflammasomes lead to the activation of a caspase. Activated caspases allow the release of mature forms of interleukin-1β and interleukin-18 and trigger a specific pro-inflammatory cell death termed pyroptosis. Accumulating data suggest that inflammasomes, mainly NLRP3, NLRP1, and AIM2, are involved in the generation of tissue damage and immune dysfunction after trauma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inflammosome Activation |
| + |
AIM2 inflammasome | up-regulates
|
Pyroptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30166988 |
Once activated by a ligand, inflammasomes lead to the activation of a caspase. Activated caspases allow the release of mature forms of interleukin-1β and interleukin-18 and trigger a specific pro-inflammatory cell death termed pyroptosis. Accumulating data suggest that inflammasomes, mainly NLRP3, NLRP1, and AIM2, are involved in the generation of tissue damage and immune dysfunction after trauma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inflammosome Activation |
| + |
NLRP3 inflammasome | up-regulates
|
Pyroptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30166988 |
Once activated by a ligand, inflammasomes lead to the activation of a caspase. Activated caspases allow the release of mature forms of interleukin-1β and interleukin-18 and trigger a specific pro-inflammatory cell death termed pyroptosis. Accumulating data suggest that inflammasomes, mainly NLRP3, NLRP1, and AIM2, are involved in the generation of tissue damage and immune dysfunction after trauma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inflammosome Activation |
| + |
GSDMD | up-regulates
|
Pyroptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256416 |
|
|
|
|
| pmid |
sentence |
| 26375003 |
These results establish that proteolytic cleavage at Asp275 in GSDMDis sufficient to instructmammalian cells to undergo pyroptosis |
|
| Publications: |
1 |
| Pathways: | Inflammosome Activation |
3.0
Pyroptosis