| + |
ATF4 | up-regulates quantity by expression 
transcriptional regulation
|
NLRP1 inflammasome |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260354 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26086088 |
Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression During Endoplasmic Reticulum Stress. Here we report that expression of NLRP1, a core inflammasome component, is specifically up-regulated during severe ER stress conditions in human cell lines. Both IRE1α and PERK, but not the ATF6 pathway, modulate NLRP1 gene expression. Furthermore, using mutagenesis, chromatin immunoprecipitation and CRISPR-Cas9-mediated genome editing technology, we demonstrate that ATF4 transcription factor directly binds to NLRP1 promoter during ER stress. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2AK2 | up-regulates activity
binding
|
NLRP1 inflammasome |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263118 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22801494 |
Here we identify a role for double-stranded RNA-dependent protein kinase (PKR, also known as EIF2AK2) in inflammasome activation. PKR physically interacts with several inflammasome components, including NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3), NLRP1, NLR family CARD domain-containing protein 4 (NLRC4), absent in melanoma 2 (AIM2), and broadly regulates inflammasome activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inflammosome Activation |
| + |
NLRP1 inflammasome | up-regulates 
|
Pyroptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260355 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30166988 |
Once activated by a ligand, inflammasomes lead to the activation of a caspase. Activated caspases allow the release of mature forms of interleukin-1β and interleukin-18 and trigger a specific pro-inflammatory cell death termed pyroptosis. Accumulating data suggest that inflammasomes, mainly NLRP3, NLRP1, and AIM2, are involved in the generation of tissue damage and immune dysfunction after trauma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Inflammosome Activation |
| + |
PAMPs | up-regulates activity
|
NLRP1 inflammasome |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263125 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| Pathways: | Inflammosome Activation |
| + |
PYCARD | form complex 
binding
|
NLRP1 inflammasome |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256408 |
|
|
|
|
| pmid |
sentence |
| 30288079 |
Canonical inflammasomes form activation platforms for caspase-1. Their assembly depends on some dedicated cytosolic PRRs from the nucleotide-binding domain leucin-rich repeat (NLR) family including NLR and pyrin domain containing receptor 1 (NLRP1), NLRP3, and NLR and caspase recruitment domain containing receptor 4 (NLRC4); the AIM2-like receptors (ALR) family including absent in melanoma 2 (AIM2); or the tripartite motif (TRIM) family including pyrin. |
|
| Publications: |
1 |
| + |
NLRP1 | form complex
binding
|
NLRP1 inflammasome |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256407 |
|
|
|
|
| pmid |
sentence |
| 30288079 |
Canonical inflammasomes form activation platforms for caspase-1. Their assembly depends on some dedicated cytosolic PRRs from the nucleotide-binding domain leucin-rich repeat (NLR) family including NLR and pyrin domain containing receptor 1 (NLRP1), NLRP3, and NLR and caspase recruitment domain containing receptor 4 (NLRC4); the AIM2-like receptors (ALR) family including absent in melanoma 2 (AIM2); or the tripartite motif (TRIM) family including pyrin. |
|
| Publications: |
1 |
| + |
NLRP1 inflammasome | up-regulates activity
cleavage
|
Caspase 1 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256380 |
|
|
|
|
| pmid |
sentence |
| 30288079 |
Canonical inflammasomes form activation platforms for caspase-1. Their assembly depends on some dedicated cytosolic PRRs from the nucleotide-binding domain leucin-rich repeat (NLR) family including NLR and pyrin domain containing receptor 1 (NLRP1), NLRP3, and NLR and caspase recruitment domain containing receptor 4 (NLRC4); the AIM2-like receptors (ALR) family including absent in melanoma 2 (AIM2); or the tripartite motif (TRIM) family including pyrin. |
|
| Publications: |
1 |
| Pathways: | Inflammosome Activation |
| + |
CASP1 | form complex
binding
|
NLRP1 inflammasome |
0.792 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256406 |
|
|
|
|
| pmid |
sentence |
| 30288079 |
Canonical inflammasomes form activation platforms for caspase-1. Their assembly depends on some dedicated cytosolic PRRs from the nucleotide-binding domain leucin-rich repeat (NLR) family including NLR and pyrin domain containing receptor 1 (NLRP1), NLRP3, and NLR and caspase recruitment domain containing receptor 4 (NLRC4); the AIM2-like receptors (ALR) family including absent in melanoma 2 (AIM2); or the tripartite motif (TRIM) family including pyrin. |
|
| Publications: |
1 |
3.0
NLRP1 inflammasome
CPX-4082