| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259956 |
|
|
Mus musculus |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 8079170 |
Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. [...]An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor. |
|
3.0
Lymphopoiesis
